Table 2

Effect of renal blood flow on the pharmacokinetics of hBNP resulting from continuous i.v. infusion

TimeBilateral Sham Ligation plasma hBNPBilateral Renal Artery Ligation plasma hBNP
min ng/ml ng/ml
00.06  ± 0.030.05  ± 0.08
504.8  ± 1.55.3  ± 2.2
557.3  ± 2.85.2  ± 2.7
605.9  ± 2.05.1  ± 1.6
1107.3  ± 2.39.7  ± 3.5
1155.8  ± 3.010.3  ± 4.1
1205.4  ± 2.98.9  ± 4.5
  • Plasma levels of hBNP before (time 0) and during continuous i.v. infusion of hBNP at 0.1 μg/kg/min. Bilateral renal artery ligation or bilateral sham procedure (n = 6 per group) was performed immediately after drawing the 60-min sample.