Table 1

Pharmacokinetics of hBNP resulting from a dose-escalating continuous i.v. infusion protocol

hBNP infusion rateTimePlasma hBNP
min ng/ml
0.05 μg/kg/min502.7  ± 0.5
552.4  ± 0.2
602.3  ± 0.04
0.1 μg/kg/min1105.9  ± 1.0
1155.8  ± 1.0
1205.4  ± 1.2
0.2 μg/kg/min17011.3  ± 1.5
17512.4  ± 1.8
18011.9  ± 2.3
  • Plasma hBNP concentrations during continuous i.v. infusion of hBNP in conscious rabbits (n = 6) at 0.05, 0.1, and 0.2 μg/kg/min initiated at 0, 60, and 120 min, respectively.