Table 2

Effects of M3 receptor inactivation, AF-DX 116 (1 μM), and pertussis toxin on the response predicted by model I

CaseM3 Receptor InactivationIncrease in EC50Value2-aDecrease in Maximal Response2-aDextral Shift Produced by AF-DX 116 (1 μM)2-bDextral Shift Produced by Pertussis Toxin2-bDecrease in Maximal Produced by Pertussis Toxin2-b
% fold % %
10N.A.N.A.2.31.00
905.604.22.00
9929.43.95.54.948.2
99.8148.550.53.61.692.3
20N.A.N.A.4.11.90
904.605.04.70
9945.63.92.75.948.1
99.8264.650.22.31.992.3
30N.A.N.A.5.04.30
908.702.75.50.9
99101.33.92.35.948.1
99.8591.350.22.31.792.3
  • 2-a This parameter was calculated by comparison with the control (0% M3 inactivation) curve.

  • 2-b This parameter was calculated by comparison with the curve of equal receptor inactivation.