Table 1

Effects of 4-DAMP mustard and pertussis toxin on the contractile response to oxotremorine-M

ConditionpEC50ParameterpKA1-a
% receptor inactivation
Control7.4  ± 0.17N.A.N.A.
1-h 4-DAMP6.66  ± 0.1693.76.21
2-h 4-DAMP6.5  ± 0.0897.66.27
3-h 4-DAMP6.34  ± 0.1098.86.01
4-h 4-DAMP6.24  ± 0.1198.76.12
Pertussis toxin + 1-h 4-DAMP5.26  ± 0.3499.34.83
Pertussis toxin + 2-h 4-DAMP1-b 5.07  ± 0.7399.25.35
Pertussis toxin + 4-h 4-DAMP4.38  ± 0.41
  • 1-a pKA value was determined according to the method of Furchgott as described in the text.

  • 1-b Data from Sawyer and Ehlert (1998).