Table 2

K_i values for inhibition of (3S)-3-hydroxylation and N-oxidation

Drug/compound	K_i
Drug/compound	3-OH-Q	Q-N-OX
	μM	μM
Ketoconazole	0.15	0.23
Bifonazole	0.48	0.59
Itraconazole	0.49	1.0^2-a
Fluconazole	14.9	19.8^2-a
Astemizole	5.7	33.9
Terfenadine	10.1	21.6
Bromocriptine	0.8	1.6
Dihydroergotamine	1.2	1.0
Vinblastine	4.7	5.9
Vincristine	24.8	27.2
Paclitaxel	58.5^2-a	54.8^2-a
Nitrendipine	20.2	14.1^2-b
Nifedipine	28.2^2-b	^2-c
Felodipine	83.8^2-b	^2-c
Erythromycin	28.4	35.2
Triacetyloleandomycin	2.3	2.9
Ciclosporin A	2.3	3.2
Midazolam	4.3	7.2
Gestodene	33.4	73.5
Ethinylestradiol	107.6	^2-c
Naringenin	109.8	103.2^2-b
Nefazodone	1.9	1.9

Values for inhibition by 22 drugs/compounds. Values represent mean of values from three inhibition studies.

↵2-a K_i value is mean ofK_i values from two inhibition studies.
↵2-b K_i value from one inhibition study.
↵2-c No inhibition with inhibitor concentrations up to 125 μM.