Ki values for inhibition of (3S)-3-hydroxylation and N-oxidation
Drug/compound | Ki | |
---|---|---|
3-OH-Q | Q-N-OX | |
μM | μM | |
Ketoconazole | 0.15 | 0.23 |
Bifonazole | 0.48 | 0.59 |
Itraconazole | 0.49 | 1.02-a |
Fluconazole | 14.9 | 19.82-a |
Astemizole | 5.7 | 33.9 |
Terfenadine | 10.1 | 21.6 |
Bromocriptine | 0.8 | 1.6 |
Dihydroergotamine | 1.2 | 1.0 |
Vinblastine | 4.7 | 5.9 |
Vincristine | 24.8 | 27.2 |
Paclitaxel | 58.52-a | 54.82-a |
Nitrendipine | 20.2 | 14.12-b |
Nifedipine | 28.22-b | 2-c |
Felodipine | 83.82-b | 2-c |
Erythromycin | 28.4 | 35.2 |
Triacetyloleandomycin | 2.3 | 2.9 |
Ciclosporin A | 2.3 | 3.2 |
Midazolam | 4.3 | 7.2 |
Gestodene | 33.4 | 73.5 |
Ethinylestradiol | 107.6 | 2-c |
Naringenin | 109.8 | 103.22-b |
Nefazodone | 1.9 | 1.9 |