Table 1

Kinetic parameters for quinidine metabolism

Liver3-OH-QQ-N-OX
VmaxKmVmax/KmVmaxKmVmax/KmL
nmol/mg/h μM ml/mg/h nmol/mg/h μM ml/mg/h ml/mg/h
HL185.577.61.123.9131.60.20.009
HL241.175.10.59.269.20.10.024
HL370.969.31.014.977.90.20.036
Mean65.874.00.916.092.90.20.023
S.D.22.64.30.37.433.80.10.014

Values are estimated by nonlinear regression analysis, using one-enzyme model for (3S)-3-hydroxylation and two-enzyme model for theN-oxidation. L is ratioVmax/Km for low-affinity enzyme involved in N-oxidation.