Distribution coefficients (D)- for (R,S)-ketorolac, INDO, and DS measured in a 1-octanol/water system at 25°C and an ionic strength of 0.15 M KCl (pH 7.4)
| Compound | pKa4-a | logP4-b | logPi4-c | D4-d(pH 7.4) | Ratio4-e |
|---|---|---|---|---|---|
| (R,S)-ketorolac | 3.5 | 2.74 ± 0.02 | −0.52 ± 0.07 | 0.40 | 1 |
| DS | 4.0 | 4.33 ± 0.01 | 0.56 ± 0.02 | 14.1 | 35 |
| IND | 4.2 | 4.08 ± 0.01 | 0.47 ± 0.02 | 12.3 | 30 |
↵4-a pKa values for (R,S)-ketorolac (Muchowski et al., 1985), DS, and INDO (Sallmann, 1979) were obtained from previously published reports.
↵4-b logP, partition coefficient of the neutral species.
↵4-c logP1, partition coefficient of the ionized species.
↵4-d D, Distribution coefficient determined at pH 7.4.
↵4-e Ratio: ((x)/D(ketorolac), where xis INDO or DS, respectively.