Comparison of ED50 values for the inhibition of dorsal raphe cell firing by 8-OH-DPAT, WAY 100635, NDL-249, and NAD-299
| Drug | ED50 | ED50 | n |
|---|---|---|---|
| μg/kg | μmol/kg | ||
| 8-OH-DPAT | 1.3 ± 0.3 | 0.004 ± 0.0009 | 14 |
| WAY 100635 | 330 ± 110 | 0.6 ± 0.2* | 5 |
| NDL-249 | 250 ± 107 | 0.7 ± 0.3** | 7 |
| NAD-299 | 435 ± 216 | 0.9 ± 0.4*** | 6 |
| p-MPPI | 6 |
Value significantly different from 8-OH-DPAT: * p < .001; ** p < .003; *** p < .002.