Table 2

Effects on the % net AUC of extracellular DA levels in the mPFC and the NAC

Drugmg/kg% net AUC (mean ± S.E.M.)
mPFCNAClog[mPFC]−log[NAC]
VEH09  ± 37 (6)−13  ± 14 (6)
APZ2351  ± 82** (6)16  ± 23 (9)1.35
101310  ± 287*** (5)135  ± 21*** (5)0.99
CLOZ5321  ± 70** (6)78  ± 34* (7)0.62
20556  ± 142** (7)133  ± 38* (6)0.63
OLAN1202  ± 66* (7)181  ± 70** (6)0.05
10560  ± 82*** (6)280  ± 39** (6)0.30
RISP0.1208  ± 26* (4)265  ± 76*** (4)−0.10
1358  ± 79*** (4)454  ± 33*** (4)−0.11
SUL10153  ± 36* (6)384  ± 49*** (8)−0.40
25266  ± 101** (4)286  ± 60** (4)−0.03
HAL0.188  ± 29 (4)300  ± 100** (5)−0.54
1137  ± 45* (6)371  ± 52*** (7)−0.43
  • The values of log[mPFC]−log[NAC] are the differences in the logarithm of % net AUC between the mPFC and the NAC. Numbers of rats in each treatment group are in parentheses. * p < .05, ** p < .01, *** p < .001 by one-way ANOVA compared to the vehicle control.