Table 3

Effects of a histamine H3-receptor agonist or antagonist on haloperidol-induced catalepsy

DrugsCatalepsy
All-or-none scoring (no. of cataleptic mice)
 Haloperidol (0.25)6 /10
 (R)α-MeHA (20)0 /10
 Haloperidol + (R)α-MeHA5 /10
 Haloperidol (0.25)14 /22
 Ciproxifan (3)2 /18
 Haloperidol + ciproxifan15 /22
Duration of catalepsy (in sec, n = 20–40)
 Haloperidol (0.8)121 ± 10 
 Haloperidol (0.8) + (R)α-MeHA (20)143 ± 14 
 Haloperidol (0.8) + ciproxifan (3)128 ± 16 
  • Drugs were administered intraperitoneally at the indicated dosage (mg/kg). H3-receptor ligands were administered 2 h and haloperidol 1 h before assessment of catalepsy.