Pharmacokinetic parameters for the disposition of 1-O-gemfibrozil-β-d-glucuronide in the rat isolated perfused liver
| Parameter | Control | DBSP |
|---|---|---|
| CL (ml/min) | 8.98 ± 2.14 | 5.17 ± 1.591-a |
| T 1/2 (min) | 16.0 ± 1.39 | 26.5 ± 8.281-a |
| E | 0.30 ± 0.07 | 0.17 ± 0.051-a |
| CLint (ml/min) | 44.0 ± 15.3 | 17.7 ± 6.61-a |
| Bgg (% dose) | 72.8 ± 8.8 | 48.7 ± 7.91-a |
| [GG]LIVER (nmol/g tissue) | 3.2 ± 0.3 | 3.6 ± 1.1 |
| [GG]LIVER/PERFUSATE | 41.7 ± 14.8 | 12.6 ± 7.51-a |
| [GG]LIVER/PERFUSATE(unbound) | 139.0 ± 49.3 | 35.0 ± 20.91-a |
| [GG]BILE/LIVER | 111.3 ± 18.0 | 76.2 ± 33.4b |
[GG]LIVER denotes intrahepatic concentration of 1-O-gemfibrozil-β-d-glucuronide; [GG]LIVER/PERFUSATE and [GG]LIVER/PERFUSATE(unbound) denote liver to total perfusate and unbound perfusate concentration ratios of 1-O-gemfibrozil-β-d-glucuronide, respectively; [GG]BILE/LIVER denotes bile to liver concentration ratio of 1-O-gemfibrozil-β-d-glucuronide.
↵1-a P < .05; b P = .05.