Table 1

Pharmacokinetic parameters for the disposition of 1-O-gemfibrozil-β-d-glucuronide in the rat isolated perfused liver

ParameterControlDBSP
CL (ml/min)8.98  ± 2.145.17  ± 1.591-a
T 1/2 (min)16.0  ± 1.3926.5  ± 8.281-a
E0.30  ± 0.070.17  ± 0.051-a
CLint (ml/min)44.0  ± 15.317.7  ± 6.61-a
Bgg (% dose)72.8  ± 8.848.7  ± 7.91-a
[GG]LIVER (nmol/g tissue)3.2  ± 0.33.6  ± 1.1
[GG]LIVER/PERFUSATE 41.7  ± 14.812.6  ± 7.51-a
[GG]LIVER/PERFUSATE(unbound) 139.0  ± 49.335.0  ± 20.91-a
[GG]BILE/LIVER 111.3  ± 18.076.2  ± 33.4b
  • [GG]LIVER denotes intrahepatic concentration of 1-O-gemfibrozil-β-d-glucuronide; [GG]LIVER/PERFUSATE and [GG]LIVER/PERFUSATE(unbound) denote liver to total perfusate and unbound perfusate concentration ratios of 1-O-gemfibrozil-β-d-glucuronide, respectively; [GG]BILE/LIVER denotes bile to liver concentration ratio of 1-O-gemfibrozil-β-d-glucuronide.

  • 1-a P < .05; bP = .05.