Competitor | Ki1 | Ki2 | f1 |
---|---|---|---|
μm | μm | ||
Verapamil | 0.31 ± 0.03 | 3.6 ± 0.2 | 0.38 ± 0.16 |
R123 | 0.11 ± 0.04 | 3.4 ± 3.6 | 0.71 ± 0.08 |
Vinblastine | 0.29 ± 0.04 | 88 ± 6.1 | 0.36 ± 0.01 |
Vincristine | 0.47 ± 0.22 | 148 ± 20 | 0.23 ± 0.03 |
Ketoconazole | 1.19 ± 0.37 | 44 ± 8.9 | 0.46 ± 0.06 |
Quinidine | 2.58 ± 1.8 | 485 ± 73 | 0.21 ± 0.04 |
rac-Talinolol | 72 ± 9.1 | 1570 ± 636 | 0.26 ± 0.19 |
rac-Metoprolol | 200 ± 18 | 1750 ± 300 | 0.16 ± 0.03 |
rac-Celiprolol | 40 ± 22 | 2600 ± 930 | 0.46 ± 0.06 |
The Ki values for the two-affinity model as well as the fraction of affinities in high-affinity status (f1) (means ± S.D., n = 3).