Table 5

Comparisons of effects^5-a on locomotor activity in the 60-min and 8-h studies

Compound	1-h Study		8-h Study
Compound	Time Period	Maximum Effect (±S.E.M.)	ED₅₀ Value (95% CL)	Time Period	Maximum Effect (±S.E.M.)	ED₅₀Value (95% CL)
	min	counts/30 min	μmol/kg	min	counts/30 min	μmol/kg
Cocaine	0–30	15,193	15.32	0–30	15,873	14.32
		(±829)	(12.09–19.44)		(±844)	(5.35–38.24)
4′,4"-diF-BZT	30–60	12,449	12.06	30–60	13,877	11.07
		(±974)	(9.77–14.88)		(±767)	(8.46–14.49)
4′,4"-diF-BZT				100–130	14,269	6.94
					(±766)	(5.44–8.83)
4′,4"-diF-BZT				170–200	14,279	8.67
					(±823)	(6.66–11.29)
4′,4"-diF-BZT				210–240	14,382	10.94
					(±882)	(9.05–13.12)
4′,4"-diCl-BZT	30–60	5,495	6.98	30–60	—	82.08
		(±473)	(2.96–16.47)			(54.24–121.42)
4′,4"-diCl-BZT				160–190	8,797	7.51
					(±1,195)	(3.44–16.45)
4′,4"-diCl-BZT				340–370	6,971	13.74
					(±1,072)	(5.23–35.83)
4′-OMe-BZT	0–30	—	63.66	0–30	—	106.37
			(53.30–75.29)			(54.55–207.38)
4′-OMe-BZT				200–230	4,204	11.63
					(±515)	(6.48–20.85)
4′-CH₃-BZT	0–30	—	57.28	0–30	—	84.38
			(39.48–84.38)			(59.73–116.48)

↵5-a ED₅₀ values depicted with a normal font are for stimulation of locomotor activity, those depicted with italics are for compounds that did not significantly stimulate activity. The ED₅₀ values were calculated as described inMethods.