Effects of interactions of atropine or scopolamine with cocaine on cocaine discriminative stimulus effects in rats
| Compound | Cocaine ED50 Value | 95% Confidence Limits |
|---|---|---|
| μmol/kg | ||
| Cocaine alone | 7.97 | 5.68–11.15 |
| Cocaine with 1.0 mg/kg atropine | 2.03 | 0.56–7.32 |
| Cocaine with 3.0 mg/kg atropine | 4.65 | 3.62–5.94 |
| Cocaine with 0.1 mg/kg scopolamine | 7.38 | 2.85–19.21 |
| Cocaine with 0.3 mg/kg scopolamine | 2.00 | 1.06–3.82 |