Table 2

Efficacy of 3α-diphenylmethoxytropane analogs in substituting for cocaine in rats

CompoundABCD
% Cocaine responses over the session% Cocaine responses on the first trial% Subjects selecting the cocaine key2-a over the session% Subjects selecting the cocaine key2-a on the first trial
Cocaine91.499.566.7 [6]100 [6]
BZT48.948.033.3 [6]33.3 [6]
4′,4"-diF-BZT64.464.466.7 [3]66.7 [3]
3′,4′-diF-BZT66.766.766.7 [3]66.7 [3]
3′,4"-diF-BZT51.050.750.0 [6]66.7 [6]
3′,4′-diCl,4"-F-BZT68.166.766.7 [3]66.7 [3]
4′-Cl-BZT54.954.940.0 [5]40.0 [5]
4′-Cl-BZT (β)33.938.520.0 [5]20.0 [5]
4′,4"-diCl-BZT17.627.916.7 [6]16.7 [6]
4′,4"-diBr-BZT35.336.516.7 [6]16.7 [6]
4′-OMe-BZT12.225.10 [6]0 [6]
4′,4"-diOMe-BZT27.038.10 [4]0 [4]
4′-Br,4"-F-BZT24.524.30 [4]0 [4]
  • Correlations between Columns

  • B with A: R2 = 0.952 (F1,12 = 220.0;P < .001); C with A: R2 = 0.856 (F1,12 = 65.4; P < .001); D with A:R2 = 0.898 (F1,12 = 96.5; P< .001); C with B: R2 = 0.778 (F1,12 = 38.5; P < .001); D with B, R2 = 0.879 (F1,12 = 80.3; P < .001); D with C,R2 = 0.922 (F1,12 = 130.6; P< .001).

  • 2-a The number in brackets that follows the entry is the number of subjects responding at that dose.