Parameters1-a | TTX-S | TTX-R | ||
---|---|---|---|---|
Control | P-CTX-1 | Control | P-CTX-1 | |
A | 0.85 ± 0.03 | 0.83 ± 0.04 | 0.40 ± 0.04 | 0.64 ± 0.05** |
τf (ms) | 10.2 ± 1.6 | 7.6 ± 1.8 | 9.1 ± 1.2 | 4.5 ± 0.9* |
B | 0.15 ± 0.04 | 0.17 ± 0.04 | 0.60 ± 0.04 | 0.36 ± 0.05** |
τs(ms) | 603 ± 124 | 728 ± 225 | 859 ± 39 | 1755 ± 521 |
The time constants τf and τs represent fast and slow recovery from inactivation, respectively, in ms. A and B represent fractions of recovery described by τf and τs, respectively.
↵1-a Parameters were calculated by fitting to a double-exponential decay function (see eq. 4 in Materials and Methods). Data are presented as means ± S.E. for TTX-S (n = 7) and TTX-R (n = 6) sodium currents. * P < .05; ** P < .01 versus controls.