Table 5

Competition experiments with [3H]verapamil and [3H]vinblastine as radioligand (mean ± S.D.,n = 3)

Compound[3H]Verapamil as Radioligand[3H]Vineblastine as Radioligand
IC50IC50
μm μm
Verapamil2.5  ± 0.32.7  ± 0.6
R1230.5  ± 0.10.6  ± 0.2
Vinblastine34  ± 1.28.1  ± 1.4
Quinidine303  ± 2674  ± 6.1
Talinolol1064  ± 105398  ± 62