Table 2

The topical effects of PDE4 inhibitors on chronic oxazolone-induced contact sensitivity

CompoundPDE4A (IC50 nM)Ear Thickness (Mean % ± S.E.)IL-4 (Mean % ± S.E.)
SB 20749911520.4  ± 4.42-a 47.4  ± 6.52-b
R-Rolipram31043.3  ± 4.12-b 80.3  ± 1.42-b
CP 8063350026.8  ± 3.72-c 67.6  ± 4.52-b
  • Balb/c mice were sensitized to oxazolone as described. Topical drug treatment (500 μg/ear, b.i.d.) began on day 28 and continued daily for 6 days. Animals were assessed for ear thickness and ears were taken for cytokine analysis as described. Values for inhibition of PDE4A are from previously published results (Barnette et al., 1995; Torphy et al., 1992, 1997).

  • 2-a P <.05.

  • 2-b P <.001.

  • 2-c P <.01.