Serum anti-PCP Fab pharmacokinetics in control and NaHCO3-treated rats
| Treatment Group | Pharmacokinetic Parameters | Time-Interval CLR | ||||||
|---|---|---|---|---|---|---|---|---|
| λz (hr−1) | T½λz (hr) | VSS(liter/kg) | CLS (ml/min/kg) | CLR (ml/min/kg) | 0–3 hr (ml/min/kg) | 3–12 hr (ml/min/kg) | ||
| [3H]Fab in controls1-a | Mean | 0.09 | 7.8 | 0.38 | 1.32 | 0.7 | 1.66 | 0.26 |
| S.D. | 0.02 | 1.7 | 0.18 | 0.41 | 0.3 | 0.46 | 0.08 | |
| CV, % | 22.2 | 21.8 | 47.4 | 31.1 | 42.9 | 27.7 | 30.8 | |
| [3H]Fab with NaHCO3 1-b | Mean | 0.09 | 7.9 | 0.31 | 1.13 | 0.8 | 2.871-c | 0.11-c |
| S.D. | 0.01 | 0.3 | 0.01 | 0.21 | 0.1 | 0.85 | 0.04 | |
| CV, % | 11.1 | 3.8 | 3.2 | 18.6 | 12.5 | 29.6 | 40.0 | |
↵1-a Animals were dosed with 210 mg/kg anti-PCP Fab along with a tracer dose of anti-PCP [3H]Fab.
↵1-b Animals were dosed with 8 mEq/kg NaHCO3 2 min before anti-PCP Fab and [3H]Fab administration. Additional doses of 2 mEq/kg NaHCO3 were administered every 45 min for 3 hr.
↵1-c Statistically different from the control group (Student’st test, P < .05). All values [mean (± S.D.)] were calculated by model-independent pharmacokinetic methods.