Table 4

Comparison of DPDPE brain uptake kinetics in mice and rats

ParameterMouse4-aRat4-b
Vmax(ng/min/g brain)24.9  ± 11.032.8  ± 8.5
km (mg/ml) 9.00  ± 5.8029.2  ± 17.7
kd 4-c (ml/min/g brain) 2.6  ± 0.41.5  ± 0.4

  • ↵4-a Data represent parameter estimates ± S.D. from nonlinear regression.

  • Analysis of pooled data (n = 5/group) as described in “Methods.”

  • ↵4-b Data from Thomas et al., 1997.

  • ↵4-c Symbology used by Thomas et al. (1997); equivalent to the product of kin and Vc in the current model.