Table 2

Pharmacokinetic parameters for DPDPE disposition based on compartmental analysis^2-a

Parameters	mdr1a(−/−)/FVB^2-b		mdr1a(−/−)
Parameters	10 mg/kg	0.9 mg/kg	24 mg/kg
V_C(ml/kg)	1700 ± 244	1493 ± 124	796 ± 55
k₁₀ (min⁻¹)	0.121 ± 0.031	0.149 ± 0.015	0.266 ± 0.026
k₁₂(min⁻¹)	0.133 ± 0.014	0.109 ± 0.018	0.136 ± 0.018
k₂₁ (min⁻¹)	0.0322 ± 0.0100	0.0597 ± 0.0142	0.0292 ± 0.0076

↵2-a Data represent parameter estimates ± S.D. from nonlinear regression analysis of pooled data (n = 5/group) with a two-compartment model.
↵2-b Results are based on the simultaneous fit of a two-compartment model to data obtained from mdr1a(−/−) and FVB mice.