Table 2

Pharmacokinetic parameters for DPDPE disposition based on compartmental analysis2-a

Parametersmdr1a(−/−)/FVB2-bmdr1a(−/−)FVB
10 mg/kg0.9 mg/kg24 mg/kg
VC(ml/kg)1700  ± 2441493  ± 124796  ± 55
k10 (min−1)0.121  ± 0.0310.149  ± 0.0150.266  ± 0.026
k12(min−1)0.133  ± 0.0140.109  ± 0.0180.136  ± 0.018
k21 (min−1)0.0322  ± 0.01000.0597  ± 0.01420.0292  ± 0.0076
  • 2-a Data represent parameter estimates ± S.D. from nonlinear regression analysis of pooled data (n = 5/group) with a two-compartment model.

  • 2-b Results are based on the simultaneous fit of a two-compartment model to data obtained from mdr1a(−/−) and FVB mice.