Table 1

Noncompartmental pharmacokinetic parameters for DPDPE inmr1a(−/−) and FVB mice1-a

Parametersmdr1a(−/−)FVB
0.9 mg/kg10 mg/kg10 mg/kg24 mg/kg
Cl (ml/min/kg)198  ± 16182  ± 31203  ± 24212  ± 17
VSS(ml/kg)10.6  ± 3.312.7  ± 3.28.68  ± 1.423.46  ± 0.941-b
MRT (min)53  ± 1770  ± 2143  ± 816  ± 51-b
t1/2,β (min)27  ± 340  ± 733  ± 226  ± 13
  • 1-a Data are expressed as mean ± S.E.,n = 5 per group.

  • 1-b P < .05 vs. 10 mg/kg dose.