Physiological parameters used in the PBPK model description for rat and human
| Organ | Rat (250 g) | Human (70 kg) | ||
|---|---|---|---|---|
| Volume (ml) | Blood flow (ml/hr) | Volume (liter) | Blood flow (liter/hr) | |
| Lung | 1 | 2515 | 1.17 | 262 |
| Heart | 0.8 | 235 | 0.27 | 9 |
| Kidney | 2.3 | 554 | 0.31 | 66 |
| Bone | 15.8 | 152 | 8.7 | 15 |
| Muscle | 122 | 450 | 30 | 45 |
| Spleen | 0.6 | 38 | 0.19 | 4.6 |
| Liver | 10.3 | 708 | 1.69 | 88.7 |
| Gut | 10 | 451 | 1.89 | 66 |
| Skin | 40 | 350 | 7.8 | 18 |
| Fat | 10 | 24 | 10 | 15.6 |
| Thymus | 0.7 | 42 | 0.037 | 4.8 |