Table 4

Tissue distribution parameters for lung and liver estimated by fit using global PBPK models assuming “blood-flow-limited” tissue cellular drug uptake

OrganLD ModelNL Model
  fuT    kass    kdis    fuT       Bt     KD,TC
(hr−1)(hr−1)(μg-eq./ml)(μg/ml)
Lung0.0123.80.0210.0154.80.00066
Liver0.0062110.0550.0090140.016