Table 3

Comparison of fitting quality between PS, LD, and NL models; maximized log-likelihood function (MLLF), weighted residual sum of squares (WRSS) and Akaike’s information criterion (AIC)3-a

OrganPS ModelLD ModelNL Model
MLLFWRSSAICMLLFWRSSAICMLLFWRSSAIC
Heart−28.50.943.6−10.80.07−7.3−10.90.07−7.3
Bone−13.80.41−1.01.10.05−9.40.30.05−8.7
Muscle−8.00.43−0.811.10.02−12.910.90.03−12.8
Spleen−33.40.742.3−18.60.08−6.1−18.40.08−6.2
Gut−23.20.671.8−10.90.11−4.6−11.20.11−4.3
Skin−9.70.34−2.1−9.70.341.9−8.50.290.9
Fat−22.71.124.6−22.71.128.6−22.71.128.6
Thymus−14.10.24−4.2−9.70.12−3.8−13.20.21−0.9
  • 3-a Calculated with N = 13 for all models; P = 2 for PS, P = 4 for LD and NL models; see “Methods” (equation 7).