Table 2

Tissue distribution parameters estimated by a local PBPK model analysis assuming LD and NL models; a reference model (PS), which neglects specific intracellular binding was also attempted

OrganPS Model2-aLD ModelNL Model
 PSTC      fuT  PSTC     fuT      kass      kdis  PSTC     fuT        Bt      KD,TC
(ml/hr)(ml/hr)(hr−1)(hr−1)(ml/hr)(μg-eq./g)(μg/g)
Heart1300.0131400.0151.00.000191400.0171.90.0002
KidneyBFL2-b 0.0104.50.036BFL2-b 0.0136.30.0058
Bone3200.0174200.0312.70.0983900.106.00.060
Muscle1,9000.0292,4000.0410.550.0262,3000.0490.830.0041
Spleen600.0049740.00795.50.046740.0107.80.010
Gut3400.0123900.0171.50.0233900.0212.40.0048
Skin2900.00972900.00981.21.023000.1438.50.039
Fat790.0009790.00101,20014.4790.0013130.034
Thymus70.005690.023160.09870.1002100.015
  • 2-a This model is identical to LD model when kass= 0 and NL model when Bt = 0.

  • 2-b Blood-flow-limited tissue cellular uptake was assumed for kidney.