Table 2

Effect of delavirdine treatment of microsomal cytochrome P450 in monkeys

Dose	Total cytochrome P450	Testosterone 6β-hydroxylation	Delavirdine desalkylation
mg/kg/day	nmol/mg	nmol/min/mg
0^2-a	1.09	2.90	1.72
35	1.11 ± 0.31	1.41 ± 0.18	0.503 ± 0.162
100	0.960^2-a	0.700^2-a	0.490 ± 0.294
350	0.810 ± 0.104	0.313 ± 0.090	0.340 ± 0.131

Female cynomolgus monkeys were treated orally with delavirdine mesylate at the doses shown for four weeks followed by preparation and evaluation of hepatic microsomes. Values shown are mean ± S.D. of three subjects.

↵2-a n = 2.