Table 1

Evaluation of microsomal cytochrome P450 in rats treated for 4 weeks with delavirdine mesylate

DoseTotal cytochrome P450Erythromycin demethylationDelavirdine desalkylationResidual delavirdineResidual desalkyl delavirdine
mg/kg/day nmol/mg protein nmol/min/mg nmol/mg protein
01.12  ± 0.051.18  ± 0.071.69  ± 0.30
1001.12  ± 0.120.347  ± 0.0951-a 0.110  ± 0.0601-a 1.08  ± 0.240.064  ± 0.023
2500.904  ± 0.1880.293  ± 0.0421-a 0.071  ± 0.0281-a 4.96  ± 1.220.075  ± 0.016

Rats were treated daily with the divided doses for 4 weeks followed by preparation and assay of liver microsomes. Values shown are mean ± S.D. of three subjects.

  • 1-a Significantly different from control (0 mg/kg/day) at 5% level.