Inhibition of (+)-PD 128,907- and (+)-7-OH-DPAT-induced hypothermia by dopaminergic antagonists
| (+)-PD 128,907 (0.63 mg/kg) | (+)-7-OH-DPAT (0.16 mg/kg) | |||
|---|---|---|---|---|
| ID50 | 95% CL | ID50 | 95% CL | |
| (±)-S 11566 | 0.35 | 0.19–0.62 | 0.3 | 0.2–0.4 |
| (+)-S 14297 | 0.59 | 0.56–2.54 | 0.4 | 0.2–0.6 |
| (−)-S 17777 | >10.0 | — | 6.5 | 3.3–12.7 |
| GR 103,691 | >10.0 | — | >10.0 | — |
| U 99194 | 12.9 | 5.12–32.3 | 19.1 | 4.7–76.7 |
| Nafadotride | 0.63 | 0.36–1.11 | 0.7 | 0.4–1.3 |
| (+)-UH 232 | 0.38 | 0.20–0.72 | 0.4 | 0.2–0.7 |
| (+)-AJ 76 | 1.02 | 0.51–1.02 | 0.5 | 0.2–0.8 |
| Haloperidol | 0.014 | 0.007–0.029 | 0.02 | 0.01–0.03 |
Doses are in mg/kg s.c.