α1-Adrenoceptor density in control and chloroethylclonidine-treated murine tissues
| Tissue | Control | Chloroethylclonidine treatment | |
|---|---|---|---|
| (fmol/mg protein) | (fmol/mg protein) | (% of control) | |
| Cerebral cortex | 109.5 ± 12.3 | 11.1 ± 2.3b | 11 ± 2 |
| Cerebellum | 70.0 ± 5.4 | 14.5 ± 7.81-a | 21 ± 12 |
| Liver | 50.1 ± 4.0 | 0.8 ± 0.8c | 1 ± 1 |
| Lung | 39.2 ± 3.2 | 10.6 ± 5.3b | 26 ± 12 |
| Kidney | 30.0 ± 2.2 | 0.4 ± 0.2b | 1 ± 1 |
| Heart | 4.9 ± 0.3 | 0.5 ± 0.2b | 11 ± 4 |
Data are means ± S.E.M. from four to five experiments and are given in fmol/mg protein or as % of the paired control as indicated. Chloroethylclonidine treatment was performed during a 30-min incubation with 10 μM at 37°C followed by two washout centrifugations.
↵1-a P < .05, b .01 and c .001, respectively, versus control in a paired, two-tailedt test.