Table 2

Effect of unlabeled substrates on the efflux of [3H]TC from the brain after microinjection into the cerebral cortex

InhibitorInjected Amount (nmol/0.2 μl injectate)kefflux (% of Control)
Control100  ± 4.2
PAH10120  ± 7
Probenecid2017.9  ± 1.32-a
ICG1107  ± 4
BSP0.591.2  ± 36.3
DBSP1101  ± 3
d-Tubocurarine665.8  ± 10.3
TEMA1082.1  ± 18.5
  • The 0.2 μl physiological buffer containing [3H]TC, [14C]inulin and unlabeled substrates was injected into the rat cerebral cortex. The kefflux was determined from the isotope content remaining in the brain at 15 min after microinjection. Results are given as a % of control. Each value represents the mean ± S.E. of three independent experiments.

  • 2-a P < .05, Significantly different from the control by ANOVA followed by Dunnett’s test.