Compound | ETB1-mediated Dilation IC50(nM) | ETB2-mediated Constriction Kb(nM) |
---|---|---|
SB 234551 | 7000 | 555 ± 119 |
SB 217242 | 70 | 353 ± 155 |
SB 209670 | 4 | 16 ± 3 |
Bosentan | 2000 | 1303 ± 1019 |
BQ-788 | 300 | 1499 ± 1016 |
RES 701 | 300 | >10,000 |
All compounds were evaluated at 10 μM; n = 4 to 5.