Table 1

Inhibition of [¹²⁵I]-tyr^osauvagine binding to CRH receptors in 293E_CRH1 and 293E_CRH2α

Drug	IC₅₀ (nM)
Drug	293E_CRH1	293E_CRH2α
1. Sauvagine	7.30 ± 0.60	2.73 ± 0.83
2. Urotensin I	1.07 ± 0.14	1.26 ± 0.39
3. Urocortin	3.76 ± 0.72	3.60 ± 0.20
4. o-CRH	7.16 ± 1.41	86.4 ± 25.4
5. r/h-CRH	4.43 ± 0.43	12.2 ± 3.63
6. α-hel	15.3 ± 1.66	6.82 ± 0.46
7. SA631	19.1 ± 7.67	>10,000
8. SC241	3.25 ± 0.74	>10,000

Binding was performed in the presence of 150 pM [¹²⁵I]-tyr^osauvagine.