Table 1

Comparison of the potency and efficacy of nicotinic agonists for recombinant human α3 AChRs

	ACh^1-165		Nicotine^1-165		Cytisine		DMPP
	EC₅₀^1-150	nH	EC₅₀^1-150	nH	Efficacy^1-160	EC₅₀^1-150	nH	Efficacy^1-160	EC₅₀^1-150	nH	Efficacy^1-160
α3β2	26 ± 0.3	0.9	6.8 ± 0.5	1.0	55%	71 ± 20	1.1	23%	2.1 ± 0.2	1.2	107%
α3β2α5	0.5 ± 0.6	1.4	1.9 ± 0.3	1.5	100%	70 ± 23	1.0	13%	10 ± 3	1.0	183%
α3β4	163 ± 6	1.9	106 ± 4	2.0	100%	76 ± 4	1.7	56%	10 ± 2.2	2.2	100%
α3β4α5	122 ± 20	1.7	105 ± 4.0	2.0	100%	20 ± 4	1.2	47%	20 ± 5	2.0	13%

↵1-150 μM
↵1-160 Maximum currents normalized to the maximum current induced by a saturating concentration of ACh.
↵1-165 Values from Wang et al. (1996) are shown for comparison.