Table 1

Analysis of saturation binding of [3H]LTB4 to high- and low-affinity receptors in the absence and presence of CP-195543

ReceptorControlCP-195543
4 nM8 nM
High affinity (n = 5)
K d (nM)1.17  ± 0.210.79  ± 0.171.28  ± 0.58
B max (×103 sites/cell)23.2  ± 2.411.2  ± 3.11-150 8.2  ± 1.81-150
Low affinity (n = 3)
K d (nM)6.47  ± 0.6615.0  ± 3.11-150
B max(×103 sites/cell)54.4  ± 4.259.3  ± 10.2
  • 1-150  P < .05: Control vs. CP-195543 (analysis of variance and Dunnett’s t-test).