Table 2

Binding affinity and in vivo potency of nonmethylated pyrrole-derived cannabinoids2-a

RR′KiSAMPERTRIRat DD
nM
n-MethylH>10,000106No max53.3NTNT
n-EthylH>10,00084.2No max77.2NTNT
n-PropylH>10,00085.981.890.1NTNT
n-ButylH666  ± 77No maxNo max>108.3NTNT
n-PentylH87  ± 33.61.278.898.916.1
n-HexylH399  ± 1098.89.662.867.822.3
n-HeptylH309  ± 1111.09.752.1No maxNT


Graphic

  • 2-a See legend to table 1.