Table 1

Biochemical effects of repeated SR141716A (SR) injections in vehicle and tolerant rats

mRNACerebral AreasTolerantSR141716A Injection
FirstSecondThird
SR aloneabstinentSR aloneabstinentSR aloneabstinent
CB1cortex=1-a ======
receptorcaudate-putamen30↓*======
αscortex20↓*======
thalamus= 24↑*=29↑*25↑*25↑*26↑*
hypothalamus= ==15.5↑*15↑*17.5↑*16.5↑*
mesencephalon25↓*=24↓*15↑*22↑*==
αocortex= ======
caudate-putamen19↓*======
olfactory area22↓*======
αicortex22↓*20↓*=====
thalamus/hypothalamus38↓**25↓*===20↑21↑
mesencephalon43↓**40↓**30↓*====

“SR alone” means CP vehicle + SR; “abstinent” is the group of rats tolerant to CP-55,940 and treated with SR141716A. The values in tolerant rats are reported for comparison. The values are percentages of the vehicle + vehicle group.

  • 1-a = alterations within 15% of vehicle; ↓ lower than vehicle; ↑ higher than vehicle; * P < .05; ** P < .01vs. vehicle + vehicle.