Comparison of receptor affinities: CB2
| Ki | ||||
|---|---|---|---|---|
| CB23-a | CB2 | D80N | D80E | |
| nM | ||||
| CP-55,940 | 1.9 ± 0.7 | 0.88 ± 0.09 | 0.48 ± 0.04 | 0.60 ± 0.20 |
| WIN-55,212-2 | 6.8 ± 0.6 | 0.14 ± 0.01† | 0.48 ± 0.09† | 0.19 ± 0.06† |
| Δ9-THC | 11.8 ± 0.7 | 44.9 ± 12.6 | 16.8 ± 1.3 | 25.6 ± 11.2 |
| (−)11-OH-Δ8-THC-DMH | 0.38 ± 0.01 | 0.49 ± 0.21 | 0.25 ± 0.05 | |
Values from competition assays with 0.5 nM [3H]CP-55,940 are presented (means ± S.E. from three experiments).
↵3-a CB2 binding in spleen from Schatz et al.(1997).
† Different from spleen (P < .05).