Brain and plasma levels of tritium after oral dosing of 1 and 10 mg/kg [3H]linopirdine
| [3H]Linopirdine Dose (mg/kg) | Time (min) | Plasma Tritium Level (μM) | Hippocampal Tritium Level (μM) |
|---|---|---|---|
| 1 | 15 | 0.32 ± 0.14 | 0.043 ± .022 |
| 1 | 30 | 0.24 ± 0.061 | 0.075 ± 0.027 |
| 10 | 15 | 13.0 ± 0.87 | 2.5 ± 0.32 |
| 10 | 30 | 9.5 ± 2.2 | 1.9 ± 0.37 |
Levels were measured as described in “Methods.” Data are represent the mean ± S.E.M. from three individual animals.