Table 1

Brain and plasma levels of tritium after oral dosing of 1 and 10 mg/kg [3H]linopirdine

[3H]Linopirdine Dose (mg/kg)Time (min)Plasma Tritium Level (μM)Hippocampal Tritium Level (μM)
1150.32  ± 0.140.043  ± .022
1300.24  ± 0.0610.075  ± 0.027
101513.0  ± 0.872.5  ± 0.32
10309.5  ± 2.21.9  ± 0.37
  • Levels were measured as described in “Methods.” Data are represent the mean ± S.E.M. from three individual animals.