Table 1

Effect of GDP concentration on the ability of three cannabinoid receptor agonists to stimulate [35S]GTPγS binding in rat cerebellar membranes

AgonistGDP concentrationEmax
μM % Stimulation of binding
CP 55,9401061  (32–91)
100114  (97–131)
WIN 55212-21089  (75–109)
100156  (144–169)
THC1051  (46–57)
100N/A
  • NA, not applicable; no significant concentration-dependent stimulation.

  • The numbers in parentheses represent 95% confidence limits.