Effect of cytokines on nitric oxide synthesis by human hepatocytes
| Treatment | Nitrite3-a |
|---|---|
| nmol/well | |
| Control | 1.6 ± 0.2 |
| OSM | 1.8 ± 0.3 |
| IL-6 | 1.4 ± 0.2 |
| LIF | 1.5 ± 0.1 |
| IL-11 | 1.8 ± 0.3 |
| IFN | 3.4 ± 0.4 |
| G-CSF | 1.7 ± 0.2 |
Nitric oxide synthesis was measured as acummulative nitrite levels in culture medium.
↵3-a After 24 hr of culture, human hepatocytes were not exposed to anything or exposed to 25 U/ml OSM, 100 U/ml IL-6, 100 U/ml LIF, 75 U/ml IL-11, 300 U/ml IFN and 320 U/ml G-CSF, and nitrite levels were evaluated 24 hr later.