Table 3

Control data

% PTZ-like AnimalsHorizontal DistanceVertical Activity
Control 0 1594.6  ± 156.3198.6  ± 22.0
1× ED50ganaxolone 0 1603.8  ± 191.0199.2  ± 43.8
1× ED50 valproate 0 2497.1  ± 397.5183.0  ± 40.2
2× ED50valproate 25 1709.1  ± 625.211.3  ± 5.6*
4× ED50 valproate100*0.0  ± 0.0*0.0  ± 0.0*
1× ED50ethosuximide 0 1793.8  ± 175.6240.4  ± 29.0
6× ED50ethosuximide 0 1877.0  ± 529.329.8  ± 24.7*
1× ED50clonazepam 0 1953.4  ± 283.3104.8  ± 25.6
8× ED50 clonazepam12.53592.5  ± 1140.6*9.5  ± 3.8*
1× ED50diazepam 0 1239.0  ± 79.4166.3  ± 25.6
8× ED50 diazepam12.52309.2  ± 451.937.6  ± 13.3*
16× ED50 diazepam37.51277.9  ± 555.131.6  ± 12.8*
1× ED50phenobarbital 0 2073.3  ± 346.0228.5  ± 47.0
8× ED50phenobarbital 0 2972.0  ± 580.9*209.8  ± 32.4

The percentage of mice exhibiting PTZ-like behaviors att = 30 min, the mean horizontal distance ± S.E.M. and the mean vertical activity ± S.E.M. for the drugs given without PTZ (n ≥ 8). Doses are in multiples of the anticonvulsant ED50 (see caption to fig. 1). * indicates a significant difference from vehicle control (P < .05) as calculated by Dunnett’s two-tailed test.