Table 2

ED50 values for reversing PTZ-induced behaviors

Observed BehaviorTotal DistanceVertical Activity
mg/kgpart of ED50mg/kgpart of ED50mg/kgpart of ED50
Ganaxolone0.540.161.310.381.940.56
(0.16–1.79)(0.047–0.52)(0.68–2.55)(0.20–0.74)(0.90–4.16)(0.26–1.21)
Valproate
Ethosuximide188.21.98257.392.71
(31.7–1116)(0.33–11.75)(165–400) (1.74–4.21)
Clonazepam0.433.070.372.62
(0.11–1.70)(0.79–12.14)(0.26–0.51)(1.89–3.63)
Diazepam1.726.621.194.56
(0.90–3.28)(3.46–12.62)(0.69–2.04)(2.56–7.85)
Phenobarbital9.021.5011.321.8912.712.12
(6.38–12.8)(1.06–2.13)(8.41–15.25)(1.40–2.54)(9.26–17.43)(1.54–2.90)

ED50 values (95% CL in parentheses) (n = 8/dose) for reversing PTZ-induced behavior, both in milligrams per kilogram and as multiples of the ED50 for preventing convulsions in acute experiments against 70 mg/kg PTZ, as determined by or according to Gasior et al. (1997a) (see caption to fig.1). The 50% effect is reached when the percentage of animals, distance or activity is half of the difference between effects of vehicle + vehicle and PTZ + vehicle. Dashes in the table indicate that the ED50 could not be calculated.