Table 2

SR 141716A blockade of hypomotility and antinociception induced by 2-methyl-2′-fluoroethylanandamide

Pretreatment2-a SR 141716A2-Methyl-2′Fluoroethylanandamide2-bSpontaneous Activity2-cAntinociception2-d
008  ± 2
30−24  ± 1018  ± 8
0137  ± 1225  ± 8
31−17  ± 162-e 39  ± 7
0353  ± 738  ± 12
33−30  ± 132-e 32  ± 7
01081  ± 384  ± 8
310−2  ± 142-e 28  ± 122-e
  • 2-a Administered i.p. 10 min before i.v. administration of 1-methyl-2′-fluoroethylanandamide. Dose expressed as mg/kg.

  • 2-b Dose expressed as mg/kg.

  • 2-c Data expressed as percent decrease in spontaneous activity of the vehicle/vehicle group and presented as means ± S.E. for 12 mice per group.

  • 2-d %MPE expressed as means ± S.E. for 12 mice per group.

  • 2-e Significantly different from the corresponding vehicle-pretreated group at P < 0.05 by Scheffe post hoc analysis.