Biliary and urinary clearance of GPFX and its glucuronide based on plasma concentrations after a single i.v. dose of [14C]GPFX to normal rats and EHBR
| Biliary Clearance (ml/min/kg) | Urinary Clearance (ml/min/kg) | |||
|---|---|---|---|---|
| Parent | 3-Glucuronide | Parent | 3-Glucuronide | |
| Normal rats | 1.79 ± 0.05 | 15.53 ± 0.90 | 0.85 ± 0.41 | 0.86 ± 0.36 |
| EHBR | 0.52 ± 0.01** | 0.09 ± 0.01** | 0.51 ± 0.11 | 0.65 ± 0.13 |
These clearance values were calculated by dividing the amount excreted over the period up to 120 min after an administration by the AUC(0–120 min) for the plasma concentrations.
Each point represents the mean ± S.E. of three rats.
** P < .01 (significantly different from the corresponding excretion over 120 hr in normal rats using Student’s ttest).