Test | Species | ED50 | ED50 | Efficacy/Rotarod1-a | Efficacy/Rotarod1-a |
---|---|---|---|---|---|
DIAZ | LY354740 | DIAZ | LY354740 | ||
Potentiated startle (anxiety) | Rats | 0.4 | 0.3 | 19.8 | >1000 |
Elevated plus maze (anxiety) | Mice | 0.21-b | 0.51-c | 361-d | >600 |
Spontaneous activity (sedation) | Rats | 6.9 | >300 | ||
Rotarod (neuromuscular coordination) | Rats | 7.9 | >300 | ||
(7.1 i.p.) | |||||
Hexobarbital-induced sleep (interaction with CNS depressants) | Mice | 1.4 | >10 | ||
Electroconvulsive shock (CNS depression) | Mice | 0.5 (i.p.) | >200 (i.p.) | ||
Passive avoidance (learning and memory) | Mice | 3.1 | >30 |