Treatment | Plasma NOx | Change in Volume | RAD Score | Change in Body Weight | Thymus Weight | Spleen Weight | ||
---|---|---|---|---|---|---|---|---|
Primary paw | Secondary paw | Primary paw | Secondary paw | |||||
μM | μl | g | g | g | ||||
Naive | 26 ± 7 | 57 ± 59 | 58 ± 58 | 0.0 ± 0.0 | 0.0 ± 0.0 | 49.4 ± 11.2 | 496 ± 38 | 428 ± 32 |
Vehicle | 76 ± 10 | 1844 ± 412 | 1280 ± 495 | 13.2 ± 3.3 | 9.6 ± 4.5 | 13.9 ± 4.5 | 275 ± 66 | 768 ± 111 |
l-NIL (60 mg/kg/day) | 26 ± 6** | 2395 ± 547 | 1142 ± 525 | 14.1 ± 4.2 | 10.5 ± 5.3 | 8.2 ± 7.3 | 216 ± 78 | 614 ± 78 |
Vehicle or compounds were administered twice daily beginning 14 days after injection of adjuvant. Paw volumes and body weights are expressed as the change from day 0. Plasma NOx levels were determined 16 hr after the last administration of compounds, after sacrifice on day 21.
* P < .05, ** P < .01 compared with the vehicle control group.