Table 2

Effect of prophylactic l-NIL treatment on primary paw swelling during adjuvant-induced arthritis in the rat.

TreatmentChange in Volume
Day 4Day 14Day 21
μl
Naive9  ± 4247  ± 4848  ± 49
Vehicle1503  ± 3962105  ± 5672464  ± 532
l-NIL (20 mg/kg/day)1433  ± 3491927  ± 6561917  ± 629*
Indomethacin (1 mg/kg/day)555  ± 183** 774  ± 133** 698  ± 161**

Vehicle or compounds were administered twice daily to rats beginning on the day of adjuvant injection (day 0). Paw volumes were determined on the days indicated after immunization with adjuvant and are expressed as the increase from day 0.

  • * P < .05, ** P < .01 compared with the vehicle control group.