Table 1

Comparison of the ability of SB 207499 to suppress immune and inflammatory cell function with rolipram

CellFunctionValue(R)-RolipramSB 207499Dose ratio1-a
μM μM
BasophilHistameIC25 0.010.2525.0
MonocytesTNF-αIC50 0.060.11.7
NeutrophilisMPOIC15 0.390.792.0
T cellsProliferationIC40 0.40.320.8
Gastric GlandsAcid SecretionEC50 0.0050.79158

  • ↵1-a Potency of SB 207499 relative to potency of (R)-rolipram.