Table 2

Comparison of Ki values for competition of LY320135 for binding to several selected neurotransmitter receptors

ReceptorKi
μM
Alpha-1 adrenergic45.3  ± 8.1
Alpha-2 adrenergic17.5  ± 0.4
Alpha adrenergic  >100
D1 897  ± 9.7
D2 441  ± 33.7
Benzodiazepine>10
H1 12.9  ± 4.8
γ-Aminobutyric acid>10
5-HT2 6.4  ± 1.9
Muscarinic2.1  ± 0.8

LY320135 was competed against ligands selective for the listed receptor. Plasma membranes were prepared from tissues expressing the receptor of interest as described under “Materials and Methods.” Data are the mean ± S.E.M. of at least three experiments, each performed in triplicate.